Neuroimaging studies provide evidence of morphological brain alterations in both population groups, particularly in the medial temporal and frontal cortices, as well as the cerebellum. These effects may be related to the amount of cannabis exposure. Functional neuroimaging studies suggest different patterns of resting global and brain activity during the performance of several cognitive tasks both in adolescents and adults, which may indicate compensatory effects in response to chronic cannabis exposure.
However, the results pointed out methodological limitations of the work conducted to date and considerable heterogeneity in the findings.
PLoS One. 2013;8(2):e55821. doi: 10.1371/journal.pone.0055821. Epub 2013 Feb 4.
Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings.
Batalla A, Bhattacharyya S, Yücel M, Fusar-Poli P, Crippa JA, Nogué S, Torrens M, Pujol J, Farré M, Martin-Santos R.
Psychiatry, Institute of Neurosciences, Hospital Clínic, IDIBAPS, CIBERSAM, Barcelona, Spain ; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain ; Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria, Australia.